Prime Male: A Scientific Review on Ingredients, Dosage, and Side Effects
Prime Male is a testosterone booster manufactured by a company called Popura. It contains a variety of vitamins, minerals, and herbs that are meant to stimulate the natural production of testosterone in the body. The primary ingredient in Prime Male is an amino acid called D-aspartic acid (D-AA).
D-AA has been shown to boost testosterone levels by up to 42% in as little as 12 days of use (source), but whether this increase sustains over the long-term still remains to be seen.
Overall, Prime Male is one of the better testosterone boosters on the market because it provides superior micronutrient support and also packs in some herbs, like mucuna pruriens and ginseng, that are proven to boost nitric oxide and improve erectile performance.
Disclaimer: My review is not based on personal experience with Prime Male. Rather, I've gone through the scientific studies behind each one of its ingredients to figure out whether it's actually proven (in human research) to boost testosterone or not.
Does Prime Male Work?
Compared to some other testosterone booster supplements I've reviewed, Prime Male definitely has a more potent and research-backed formula.
That being said, my recommendation is always to focus on diet and lifestyle before supplementation.
Supplements can help, but they should not be relied upon as the sole measure towards getting results. That's why I created this free quiz to help analyze your current situation and offer personalized advice.
Your body goes through a series of feedback loops to produce optimal levels of testosterone and this process is way too complex to be fixed with a simple pill.
The fact that you're reading this right now means that you are possibly experiencing symptoms of low testosterone (low energy, increased body fat, decreased sex drive, etc.). Or maybe you just want to build more muscle. Regardless of your situation, my recommendation to you is to first align your diet and lifestyle towards getting lean, building muscle, and optimizing sleep, after which you can focus on supplementation to help provide an edge.
So to answer the question:
Yes, Prime Male supports optimal testosterone production. But your efforts will be even more effective if you combine supplementation with a proper workout, eating, and sleeping schedule.
Prime Male Detailed Review
The main purpose of my review is to look at the research behind each one of Prime Male's ingredients. I have summarized the studies and explained my interpretations of the results.
I have done my best to remain unbiased, and I hope that my review provides you with the information you need to make an informed decision before purchase.
Prime Male Ingredient Dosages
Prime Male contains the following ingredients in the following dosages:
- Vitamin D3 (5,000 IU)
- Vitamin K2 (45 mcg)
- Vitamin B6 (7.5 mg)
- Magnesium (100 mg)
- Zinc (30 mg)
- D-Aspartic Acid (1600 mg)
- Asian Red Ginseng (120 mg)
- Luteolin (60 mg)
- Mucuna Pruriens (300 mg)
- Nettle Root (160 mg)
- BioPerine (10 mg)
- Boron (5 mg)
Now, I will go through each of these ingredients one at a time.
Vitamin D plays a part in over 1000 bodily functions. Optimal vitamin D balance is correlated with a host of health benefits; stronger bones, reduced risk of illness, reduced risk of diabetes, and cancer prevention to name a few.
As it turns out, vitamin D levels are also directly correlated with testosterone. Let's take a look at the research:
- After analyzing the blood work of 2299 men, researchers found that men with sufficient vitamin D levels had significantly higher testosterone levels compared to men who were deficient in it (1).
- Men supplementing with 3332 IU's of vitamin D daily for one year had, on average, 25% higher testosterone levels compared to placebo (2).
With 5000 IU's of it per serving, Prime Male has your vitamin D needs covered.
Studies have shown a direct inverse correlation between vitamin K levels and mortality from all causes (6).
In other words:
Maintaining optimal K2 levels means that you are less likely do die from all causes.
So what about its interaction with testosterone?
Well, there have been no human studies performed in the area, but some animal studies reveal interesting results:
- Rats given 75 mg of vitamin K2 per kg of bodyweight were found to have significantly higher testosterone levels compared to placebo (7).
- Rats with vitamin K2 deficiencies were found to have significantly lower testosterone levels compared to rats with an adequate K2 balance (8).
Vitamin K2 is an all-round super vitamin. Whether it impacts testosterone levels in human still needs further research, but the fact is:
Maintaining optimal levels of K2 will definitely enhance the overall quality of your life.
Prime Male provides 50% of your daily K2 requirement
B vitamins have an important role in many bodily processes, some of which include energy regulation, nerve function, and liver function.
There is no particular benefit of vitamin B6 on testosterone levels, but given the fact that it has a role in so many of the body's functions, it may indirectly affect the big T as well.
Magnesium is an essential mineral that has a key role in maintaining blood pressure, bone mineralization, and keeping the heart beat steady.
You must maintain an adequate magnesium balance if you want to achieve optimal testosterone levels.
Here's what the research says:
- After analyzing the blood work of 399 men over the age of 65, researchers found magnesium levels to be significantly correlated with testosterone levels (9).
- 10mg of magnesium supplementation was enough to increase testosterone levels in both sedentary and athletic subjects (10). The effect was more profound in athletes.
Magnesium deficiency is amongst the top micronutrient deficiencies in developing countries. An estimated 48% of Americans are considered to be magnesium deficient (11).
Prime Male provides 24% of your daily requirement for magnesium.
Like magnesium, zinc is another critical mineral that has been studied for its direct effect on testosterone levels:
- Professional wrestlers experienced significantly higher testosterone levels by supplementing with 3mg of zinc per kg of bodyweight (12).
- Subjects put on a stationary bike experienced higher testosterone levels by supplementing with zinc than without it (13).
Like with other micronutrients, the extent to which zinc will affect your testosterone levels is dependent on your current zinc levels. If you're deficient, then zinc supplementation will definitely boost T. If your levels are adequate, then topping up your levels even further won't have much of an impact.
Either way, Prime Male has your daily zinc requirements covered.
D-AA is the primary ingredient in many of the most popular testosterone boosters on the market today. Whether it works or not is open to interpretation.
There have been 3 human studies performed with D-AA, each of them showing a completely different result:
- 23 subjects consuming 3g of D-AA daily experienced 42% higher testosterone levels after just 12 days of supplementation (14).
- Resistance trained men supplementing with 3 grams of D-AA experienced no significant changes in T-levels compared to placebo (15).
- 24 resistance trained men were given either 3g of D-AA, 6g of D-AA, or placebo. The 3g group experienced no changes in testosterone levels compared to placebo, whereas the 6g group actually experienced lower T (16).
More human studies are needed to confirm the effectiveness of D-AA as a testosterone booster. That being said, don't worry about the negative effects of it because Prime Male only has 1.6g of D-AA.
Asian Red Ginseng
Asian red ginseng is another popular ingredient in testosterone supplements. It provides a range of health benefits ranging from (but not limited to) better mental cognition, weight-loss, and better sexual function.
Red ginseng is a nitric oxide booster, and is therefore effective at improving blood flow and treating ED (17). It has also been shown to boost testosterone levels in infertile men (18). Whether this effect carries on to fertile men, it's hard to say. More research is needed.
The 120mg dose of Asian Red Ginseng in Prime Male may not boost testosterone levels, but can provide a host of other benefits, which may indirectly increase T.
Luteolin is a flavonoid known for its anti-oxidant and anti-inflammatory properties. Some common dietary sources of luteolin include broccoli, celery, thyme, parsley, olive oil, pepper mint, and oregano.
As for its effects on hormones, I was only able to find one study:
Researchers found luteolin to have endocrine disrupting effects that increase the effect of estrogen (22).
There is only 60mg of luteolin in Prime Male, so the estrogenic effects are not likely to be so profound. Also, the study was performed in vitro, i.e. it was performed in a test tube rather on actual humans. Plus, it seems like the benefits of luteolin far outweigh the drawbacks.
Mucuna Pruriens, aka velvet bean, has traditionally been used in Indian herbal medicine to treat Parkinson's. Today, people use it as an anti-depressant, libido booster, or testosterone supplement.
The active ingredient in velvet bean is L-DOPA, the precursor for dopamine. Dopamine is a neurotransmitter in your brain that regulates your emotions, movements and your sensations of pleasure and pain.
As per its impact on testosterone, let's take a look at the studies:
- In men with chronic stress, 5g of mucuna pruriens supplementation (5 days/week) for 3 months was found to significantly lower cortisol levels and increased sperm quality (23).
- 75 infertile men and 75 healthy men were recruited to study the effects of mucuna pruriens at the dose of 5g for 3 months. At the end of the 3 months, the healthy subjects had 27% higher testosterone levels while the infertile men had about 38% higher testosterone levels (24).
- 180 infertile men supplementing with 5g of mucuna pruriens over a period of 3 months were found to have, on average, about 27% higher testosterone levels after supplementation (25).
Cortisol is the hormone your body releases when you're stressed, and it is inversely correlated with testosterone. According to the first study, Mucuna Pruriens has a direct lowering effect on cortisol. A drop in cortisol directly translates to a rise in testosterone.
Based on the research, Mucuna Pruriens seems to be a potent testosterone boosting ingredient.
Providing 3g per serving, Prime Male delivers a hefty dose of Mucuna Pruriens that can help you reduce stress and naturally boost testosterone levels in the process.
Stinging Nettle is a plant that has shown to have potent anti-inflammatory properties. It has found its way into many testosterone boosting supplements, but does it actually work?
Let's see what the research says:
- 558 men with an enlarged prostate condition were given 120mg of nettle root thrice daily over a period of 6 months. At the end of the study, the subjects that supplemented with nettle root didn't experience any changes in T-levels compared to placebo (26).
There have been some animal and test-tube studies performed with nettle root as well, but the results from them are also inconclusive.
Based on the lone human study, nettle root supplementation does not seem to impact testosterone levels. Further research is needed to confirm this interaction.
Piperine, aka BioPerine, is extracted from black pepper.
On its own, piperine does not have any significant effects. However, it has been shown to enhance the absorption of other herbs and minerals.
BioPerine may allow your body to increase absorption of the ingredients in Prime Male.
Boron is a mineral that has been studied for its interactions with testosterone. Apparently we have much less boron in our diet today compared to a couple of decades ago.
Let's take a look at what the research says:
- 8 healthy male subjects were given 10mg of boron for a period of 7 days. After 7 days of supplementation, the subjects had, on average, 28% higher free testosterone levels and 64% lower estrogen levels (27).
- 19 male bodybuilders supplementing with 2.5g of boron for 7 weeks showed no differences in testosterone levels compared to placebo (28).
In the first study, results were pretty astounding. But the problem is that the sample size was too small and so was the time of the experiment. 1 week is to short of a time span to determine the long-term effects of boron supplementation. The second study took place over a period of 7 weeks, but showed the opposite results.
More research is needed to confirm Boron's status as a testosterone boosting ingredient.
Prime Male Testimonials and Customer Reviews
There are a bunch of reputable and very detailed testimonials of Prime Male on their website. Some advocates of Prime Male include Dolph Lundgren (actor, director, producer, martial artist), Andre Reed (NFL hall of famer), and Scott Zolak (retired NFL quarterback).
Other than the high-profile testimonials, there are a bunch of them from "normal" guys as well.
Overall, I was unable to find even one negative review of Prime Male on the internet. Everyone who's used it seems to report excellent results.
Prime Male Price
Prime Male is definitely one of the more expensive testosterone booster supplements on the market.
A 4-month's supply retails for $207 ($1.72/serving). This is the only option with which they offer a 90-day money back guarantee.
A 2-month's supply retails for $138 ($2.3/serving).
A 1-month supply retails for $69 ($2.3/serving).
Prime Male Side Effects
It is always best practice to consult your healthcare practitioner before taking a supplement to make sure that the ingredients will not result in an adverse reaction.
Below, I've listed out some reported possible side-effects of each one of Prime Male's ingredients individually. Keep in mind, though, that these side-effects are only likely to occur if you drastically exceed the recommended dosage.
Possible Side Effects of D-Aspartic Acid
- Hair loss
Possible Side-Effects of Asian Red Ginseng
- Difficulty sleeping
- Upset stomach
Possible Side-Effects of Mucuna Pruriens
- Hair loss
- High blood pressure
Possible Side-Effects of Nettle Root
- Mild stomach upset
- Fluid retention
- Hives or rash
Possible Side-Effects of Boron
- Skin inflammation and peeling
How Does Prime Male Compare?
Prime Male is definitely one of the better testosterone booster supplements I've come across in terms of its ingredient formula.
For this portion of the review, let's see how it stacks up against some other popular testosterone boosters on the market.
Prime Male vs Testofuel
TestoFuel has a very similar ingredients profile to Prime Male.
D-Aspartic Acid is the primary ingredient in both of these testosterone booster supplements, but as you know, more research is needed to confirm D-AA's interaction with testosterone levels in healthy men.
That being said, Prime Male has a lower dose of D-AA and packs in some extra ingredients (mucuna pruriens, nettle root, boron, and BioPerine) that increase its effectiveness
Winner: Prime Male
Prime Male vs Virectin
The primary ingredient in Virectin is Tribulus Terrestris.
Tribulus is a very popular testosterone boosting ingredient, but studies have consistently shown its ineffectiveness at boosting testosterone levels (29, 30). That being said, Virectin is being marketed as a "male enhancement pill" and not necessarily as a testosterone booster, and tribulus has been found to have libido boosting benefits.
Higher T-levels do lead to higher libido, but higher libido does not necessarily lead to higher T-levels.
Winner: Prime Male
Prime Male vs Nugenix
Nugenix is comprised of a proprietary blend so we can't be sure of the dosage of each ingredients.
The primary ingredients in Nugenix are L-Citrulline Malate, Fenugreek, and Tribulus. L-Citrulline is a proven nitric oxide booster while fenugreek has been associated with higher T, but the research is inconclusive. Tribulus, as you know, has no impact on testosterone levels whatsoever.
Nugenix is another supplement that boosts libido but may not impact testosterone levels to any significant extent.
Winner: Prime Male
Prime Male vs Animal Stak
Animal Stak is a supplement manufactured by Universal Nutrition. They produce a bunch of popular bodybuilding supplements as well.
The primary ingredient in Animal Stak is Tribulus Terrestris. Animal Stak has a bunch of proprietary blends.
Ingredients are usually listed out in terms of dosage. The fact that tribulus is first on the list provides insight towards the ineffectiveness of Animal Stak as a testosterone booster.
There are a bunch of other blends withing Animal Stak as well, but as far as testosterone boosting abilities go, Prime Male definitely takes the cake.
Winner: Prime Male
Where To Buy Prime Male?
Prime Male is not available at GNC, Amazon, or Walmart.
To buy Prime Male you have to buy directly from their website.